International Review of Ophthalmology

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The pathogenesis and the risk factors of meibomian gland dysfunction

HUANG Zhen-qin1, DONG Tian-hui1, ZHAN Zhan-ji1, ZHOU Jie-long1, FU Min2   

  1. 1. The Second Clinical Medical College, Southern Medical University, Guangzhou 510515, China;  2. Department of Ophthalmology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
  • Received:2016-10-06 Online:2017-02-22 Published:2017-02-20
  • Contact: FU Min, Email： 3386989@qq.com
  • Supported by:

    The College Students' Innovative Entrepreneurial Training Plan in 2016(201612121273)

Abstract:

Meibomian gland dysfunction(MGD) is a chronic, diffuse abnormality of the meibomian glands characterized by terminal duct obstruction and/or qualitative/ quantitative changes in the glandular secretion. It may result in abnormality of the tear film, symptoms of eye irritation, inflammation, and ocular surface disease. The related factors about the pathogenesis of MGD are relevant to abnormal glandular secretion and terminal duct obstruction. The inflammation is believed as a critical pathogenesis. In addition, tear lipocalin and apoptosis also play important roles in the pathogenesis of MGD.   (Int Rev Ophthalmol,  2017,  41:   48-52)